Overview

  • Product name

  • Description

    Rabbit polyclonal to GALC
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Dog, Monkey
  • Immunogen

    Recombinant fragment within Human GALC aa 341-591 (internal sequence). The exact sequence is proprietary.
    Database link: P54803

  • Positive control

    • Recombinant Human GALC protein (ab116728) can be used as a positive control in WB. A431, H1299 and HeLa whole cell lysates.
  • General notes

    Protein previously labeled as Galactosylceramidase.

Properties

Applications

Our Abpromise guarantee covers the use of ab137750 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 77 kDa.

Target

  • Function

    Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
  • Tissue specificity

    Detected in urine. Detected in testis, brain and placenta (at protein level). Detected in kidney and liver.
  • Involvement in disease

    Leukodystrophy, globoid cell
  • Sequence similarities

    Belongs to the glycosyl hydrolase 59 family.
  • Cellular localization

    Lysosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • Gacy antibody
    • Galactocerebrosidase antibody
    • Galactocerebroside beta galactosidase antibody
    • Galactocerebroside beta-galactosidase antibody
    • Galactosylceramidase antibody
    • Galactosylceramide beta galactosidase antibody
    • Galactosylceramide beta-galactosidase antibody
    • galactosylceraminidase antibody
    • GALC antibody
    • GALC_HUMAN antibody
    • GALCERase antibody
    • Twitcher antibody
    see all

Images

  • Anti-GALC antibody (ab137750) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size: 77 kDa



    7.5% SDS PAGE

References

This product has been referenced in:

See 1 Publication for this product

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