Overview

  • Product name
    Anti-GALE antibody [EPR11089(B)]
    See all GALE primary antibodies
  • Description
    Rabbit monoclonal [EPR11089(B)] to GALE
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: Flow Cyt,ICC or IHC-P
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human GALE was (UniProt ID: Q14376).

  • Positive control
    • Human fetal liver, HT29 and HepG2 lysates.
  • General notes

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab155277 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 38 kDa.
IP 1/10 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,ICC or IHC-P.
  • Target

    • Function
      Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
    • Pathway
      Carbohydrate metabolism; galactose metabolism.
    • Involvement in disease
      Defects in GALE are the cause of epimerase-deficiency galactosemia (EDG) [MIM:230350]; also known as galactosemia type 3. Clinical features include early-onset cataracts, liver damage, deafness and mental retardation. There are two clinically distinct forms of EDG. (1) A benign, or 'peripheral' form with no detectable GALE activity in red blood cells and characterized by mild symptoms. Some patients may suffer no symptoms beyond raised levels of galactose-1-phosphate in the blood. (2) A much rarer 'generalized' form with undetectable levels of GALE activity in all tissues and resulting in severe features such as restricted growth and mental development.
    • Sequence similarities
      Belongs to the sugar epimerase family.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ95174 antibody
      • FLJ97302 antibody
      • Galactose 4 epimerase UDP antibody
      • Galactowaldenase antibody
      • galE antibody
      • GALE_HUMAN antibody
      • OTTHUMP00000002991 antibody
      • OTTHUMP00000002994 antibody
      • OTTHUMP00000037931 antibody
      • OTTHUMP00000044857 antibody
      • SDR1E1 antibody
      • short chain dehydrogenase/reductase family 1E member 1 antibody
      • UDP galactose 4 epimerase antibody
      • UDP galactose 4' epimerase antibody
      • UDP glucose 4 epimerase antibody
      • UDP-galactose 4-epimerase antibody
      • UDP-glucose 4-epimerase antibody
      see all

    Images

    • All lanes : Anti-GALE antibody [EPR11089(B)] (ab155277) at 1/1000 dilution

      Lane 1 : Human fetal liver lysate
      Lane 2 : HT29 lysate
      Lane 3 : HepG2 lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 38 kDa

    References

    ab155277 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab155277.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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