Overview

  • Product name

    Galiellalactone, STAT3 signaling inhibitor
  • Description

    Selective STAT3 signaling inhibitor
  • Biological description

    Selective STAT3 signaling inhibitor (IC50 = 0.25-0.5 μM, IL-6-mediated JAK/STAT signaling). Selectively blocks binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. Induces apoptosis. Shows antitumor and anti-inflammatory effects in vivo.
  • Purity

    > 95%
  • CAS Number

    133613-71-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bollmann F  et al. Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice. PLoS One 10:e0130401 (2015). Read more (PubMed: 26076475) »
  • Canesin G  et al. The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate Cancer. Eur Urol : (2015). Read more (PubMed: 26144873) »
  • Don-Doncow N  et al. Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J Biol Chem 289:15969-78 (2014). Read more (PubMed: 24755219) »

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