Overview

  • Product name

    Gallamine triethiodide, M2 receptor antagonist
  • Description

    Potent and selective M2 receptor antagonist
  • Biological description

    Potent and selective M2 receptor antagonist (Ki values are 2.4 and 24 nM for M2 and M1 respectively). Blocks delayed potassium conductance and slows sodium inactivation. Blocks neuromuscular transmission in vivo.
  • Purity

    > 99%
  • CAS Number

    65-29-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,2’,2’’-[Benzene-1,2,3-triyltris(oxy)]tris(N,N,N-triethylethanaminium) triiodide
  • Molecular weight

    891.53
  • Molecular formula

    C30H60I3N3O3
  • PubChem identifier

    6172
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=CC=CC(=C1OCC[N+](CC)(CC)CC)OCC[N+](CC)(CC)CC)OCC[N+](CC)(CC)CC.[I-].[I-].[I-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Strohmaier CA  et al. Episcleral venous pressure and IOP responses to central electrical stimulation in the rat. Invest Ophthalmol Vis Sci 54:6860-6 (2013). Read more (PubMed: 24065806) »
  • Ziyatdinova NI  et al. Peculiar effects of muscarinic M1, M2, and M3 receptor blockers on cardiac chronotropic function in neonatal rats. Bull Exp Biol Med 154:1-2 (2012). Read more (PubMed: 23330075) »
  • Burke RE Gallamine binding to muscarinic M1 and M2 receptors, studied by inhibition of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding to rat brain membranes. Mol Pharmacol 30:58-68 (1986). Read more (PubMed: 3755217) »
  • Smith KJ & Schauf CL Effects of gallamine triethiodide on membrane currents in amphibian and mammalian peripheral nerve. J Pharmacol Exp Ther 217:719-26 (1981). Read more (PubMed: 6971929) »

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