Galloflavin, Lactic acid dehydrogenase (LDH) inhibitor (ab141776)

Overview

  • Product name
    Galloflavin, Lactic acid dehydrogenase (LDH) inhibitor
  • Description
    Novel, non-competitive lactic acid dehydrogenase (LDH) inhibitor
  • Alternative names
    • NSC-107022
  • Biological description

    Novel, non-competitive lactic acid dehydrogenase (LDH) inhibitor (Ki values are 5.46 and 15.06 μM for LDH-A and LDH-B respectively). Non-competitive inhibition of pyruvate and NADH. Inhibits cell metabolism and induces cell death. Blocks RNA synthesis in vitro.

  • Purity
    > 95%
  • CAS Number
    568-80-9
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name

    6,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,3-dione

  • Molecular weight
    278.17
  • Molecular formula
    C12H6O8
  • PubChem identifier
    54683147
  • Storage instructions
    Store at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. It is important to note that this product is reported to be light sensitive. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 10 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=C2C(=C(C(=C1O)O)O)C3=C(C=C(C(=O)O3)O)OC2=O
  • Source

    Synthetic

References

This product has been referenced in:
  • Fiume L  et al. Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells. Biochem Biophys Res Commun 430:466-9 (2013). Read more (PubMed: 23237800) »
  • Manerba M  et al. Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem 7:311-7 (2012). Read more (PubMed: 22052811) »
  • Farabegoli F  et al. Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur J Pharm Sci 47:729-38 (2012). Read more (PubMed: 22954722) »

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