Overview

  • Product name

    Anti-GALNT14 antibody
  • Description

    Rabbit polyclonal to GALNT14
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human GALNT14 aa 1-552.
    Database link: Q96FL9

  • Positive control

    • WB: Rat gonad tissue lysate; Mouse kidney tissue lysate. IHC-P: Human small intestine tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab235526 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
WB 1/1000 - 1/5000.

Target

  • Function

    Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
  • Tissue specificity

    Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bladder, uterus, placenta, testis, ovary, skeletal muscle, leukocyte, B-cell, bone marrow, fetal brain, fetal thymus, fetal lung, fetal liver, fetal small intestine, fetal spleen, fetal skeletal and fetus.
  • Pathway

    Protein modification; protein glycosylation.
  • Sequence similarities

    Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • Domain

    There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Cellular localization

    Golgi apparatus membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • GalNAc T14 antibody
    • GalNAc-T14 antibody
    • Galnt14 antibody
    • GLT14_HUMAN antibody
    • Polypeptide GalNAc transferase 14 antibody
    • Polypeptide N acetylgalactosaminyltransferase 14 antibody
    • Polypeptide N-acetylgalactosaminyltransferase 14 antibody
    • pp GaNTase 14 antibody
    • pp-GaNTase 14 antibody
    • Protein UDP acetylgalactosaminyltransferase 14 antibody
    • Protein-UDP acetylgalactosaminyltransferase 14 antibody
    • UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 14 antibody
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14 antibody
    see all

Images

  • All lanes : Anti-GALNT14 antibody (ab235526) at 1/1000 dilution

    Lane 1 : Rat gonad tissue lysate
    Lane 2 : Mouse kidney tissue lysate

    Secondary
    All lanes : Goat polyclonal to rabbit at 1/10000 dilution
  • Paraffin-embedded human small intestine tissue stained for GALNT14 using ab235526 at 1/100 dilution in immunohistochemical analysis.

References

ab235526 has not yet been referenced specifically in any publications.

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