Overview

  • Product name

  • Description

    Rabbit polyclonal to GALNT3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human GALNT3 aa 1-140.
    Database link: Q14435

  • Positive control

    • IHC-P: Human small intestine and skin tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab229662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis.
  • Tissue specificity

    Expressed in organs that contain secretory epithelial glands. Highly expressed in pancreas, skin, kidney and testis. Weakly expressed in prostate, ovary, intestine and colon. Also expressed in placenta and lung and fetal lung and fetal kidney.
  • Pathway

    Protein modification; protein glycosylation.
  • Involvement in disease

    Defects in GALNT3 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement.
  • Sequence similarities

    Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • Domain

    There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Cellular localization

    Golgi apparatus > Golgi stack membrane. Resides preferentially in the trans and medial parts of the Golgi stack.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp686C10199 antibody
    • EC 2.4.1.41 antibody
    • GalNAc T3 antibody
    • GalNAc transferase 3 antibody
    • GalNAc-T3 antibody
    • GalNAcT3 antibody
    • GALNT3 antibody
    • GALT3_HUMAN antibody
    • HFTC antibody
    • HHS antibody
    • MGC61909 antibody
    • OTTHUMP00000204915 antibody
    • OTTHUMP00000204919 antibody
    • Polypeptide GalNAc transferase 3 antibody
    • Polypeptide GalNAc transferase T3 antibody
    • Polypeptide N acetylgalactosaminyltransferase 3 antibody
    • Polypeptide N-acetylgalactosaminyltransferase 3 antibody
    • pp-GaNTase 3 antibody
    • ppGaNTase 3 antibody
    • Protein UDP acetylgalactosaminyltransferase 3 antibody
    • Protein-UDP acetylgalactosaminyltransferase 3 antibody
    • RP23-306G16.2 antibody
    • UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 3 antibody
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 3 (GalNAc T3) antibody
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 antibody
    • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 antibody
    see all

Images

  • Paraffin-embedded human small intestine tissue stained for GALNT3 using ab229662 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human skin tissue stained for GALNT3 using ab229662 at 1/100 dilution in immunohistochemical analysis.

References

ab229662 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab229662.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up