Overview

  • Product name
    Gambogic acid, Apoptotic agent
  • Description
    Apoptotic agent
  • Biological description
    Cell-permeable caspase activator (EC50 = 0.78 - 1.64 µM). Apoptotic agent. Decreases Bcl-2 and increases Bax expression. Potentiates cisplatin (ab141398)-induced apoptosis. Inhibits angiogenesis. Shows antitumor effects in vivo. Orally active.
  • Purity
    > 98%
  • CAS Number
    2752-65-0
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    (2Z)-4-[(2R,8R,17R,19R)-12-Hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0[2,15].0[2,19].0[4,13].0[6,11]]docosa-4(13),5,9, 11,15-pentaen-19-yl]-2-methyl-2-butenoic acid
  • Molecular weight
    628.75
  • Molecular formula
    C38H44O8
  • PubChem identifier
    5281632
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 25 mM and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=C(O)C(/C)=C\C[C@]63OC(C)(C)[C@H]2C[C@H](C=C1C(=O)c5c(OC123)c(C\C=C(/C)C)c4O[C@](C)(CC\C=C(/C)C)C=Cc4c5O)C6=O
  • Source

    Synthetic

References

This product has been referenced in:
  • Wang LH  et al. Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-?B and MAPK/HO-1 signalling. Br J Cancer 110:341-52 (2014). Read more (PubMed: 24300974) »
  • Hua X  et al. Simultaneous determination and pharmacokinetic study of gambogic acid and gambogenic acid in rat plasma after oral administration of Garcinia hanburyi extracts by LC-MS/MS. Biomed Chromatogr : (2014). Read more (PubMed: 25159917) »
  • Jiang XL  et al. Targeting renal cell carcinoma with gambogic acid in combination with sunitinib in vitro and in vivo. Asian Pac J Cancer Prev 13:6463-8 (2012). Read more (PubMed: 23464475) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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