Key features and details
- Apoptotic agent
- CAS Number: 2752-65-0
- Purity: > 98%
- Soluble in ethanol to 25 mM and in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameGambogic acid, Apoptotic agent
Biological descriptionCell-permeable caspase activator (EC50 = 0.78 - 1.64 µM). Apoptotic agent. Decreases Bcl-2 and increases Bax expression. Potentiates cisplatin (ab141398)-induced apoptosis. Inhibits angiogenesis. Shows antitumor effects in vivo. Orally active.
Chemical name(2Z)-4-[(2R,8R,17R,19R)-12-Hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[188.8.131.52[2,15].0[2,19].0[4,13].0[6,11]]docosa-4(13),5,9, 11,15-pentaen-19-yl]-2-methyl-2-butenoic acid
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 25 mM and in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145183 has not yet been referenced specifically in any publications.