Overview

  • Product name

    Gambogic amide, nerve growth factor (TrKa) receptor agonist
  • Description

    Potent, selective high affinity nerve growth factor (TrKa) receptor agonist
  • Biological description

    Potent, selective high affinity nerve growth factor (TrKa) receptor agonist (Kd = 75 nM). Antiapoptotic and anticancer agent. Active in vitro and centrally in vivo.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Jarboe JS  et al. Kinomic profiling approach identifies Trk as a novel radiation modulator. Radiother Oncol 103:380-7 (2012). Read more (PubMed: 22561027) »
  • Chan CB  et al. NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association. Oncogene 28:3825-36 (2009). Read more (PubMed: 19668232) »
  • Jang SW  et al. Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death. Proc Natl Acad Sci U S A 104:16329-34 (2007). Read more (PubMed: 17911251) »

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