Product nameGambogic amide, nerve growth factor (TrKa) receptor agonist
DescriptionPotent, selective high affinity nerve growth factor (TrKa) receptor agonist
Biological descriptionPotent, selective high affinity nerve growth factor (TrKa) receptor agonist (Kd = 75 nM). Antiapoptotic and anticancer agent. Active in vitro and centrally in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
This product has been referenced in:
- Jarboe JS et al. Kinomic profiling approach identifies Trk as a novel radiation modulator. Radiother Oncol 103:380-7 (2012). Read more (PubMed: 22561027) »
- Chan CB et al. NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association. Oncogene 28:3825-36 (2009). Read more (PubMed: 19668232) »
- Jang SW et al. Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death. Proc Natl Acad Sci U S A 104:16329-34 (2007). Read more (PubMed: 17911251) »