Overview

  • Product name

    Anti-gamma Catenin antibody
    See all gamma Catenin primary antibodies
  • Description

    Rabbit polyclonal to gamma Catenin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rabbit, Chimpanzee, Rhesus monkey, Gorilla
  • Immunogen

    Synthetic peptide, corresponding to a region within N terminal amino acids 1-50 of Human gamma Catenin (NP_002221.1).

  • Positive control

    • Whole cell lysate from HeLa and 293T cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab134558 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 82 kDa.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function

      Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
    • Involvement in disease

      Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.
      Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
    • Sequence similarities

      Belongs to the beta-catenin family.
      Contains 9 ARM repeats.
    • Cellular localization

      Cell junction > adherens junction. Cell junction > desmosome. Cytoplasm > cytoskeleton. Membrane. Cytoplasmic in a soluble and membrane-associated form.
    • Information by UniProt
    • Database links

    • Alternative names

      • ARVD 12 antibody
      • ARVD12 antibody
      • Catenin (cadherin associated protein), gamma 80kDa antibody
      • catenin (cadherin-associated protein) gamma (80kD) antibody
      • Catenin gamma antibody
      • CTNNG antibody
      • Desmoplakin 3 antibody
      • Desmoplakin III antibody
      • Desmoplakin-3 antibody
      • Desmoplakin3 antibody
      • DesmoplakinIII antibody
      • DP 3 antibody
      • DP III antibody
      • DP3 antibody
      • DPIII antibody
      • gamma catenin antibody
      • Junction plakoglobin antibody
      • JUP antibody
      • OTTHUMP00000164732 antibody
      • OTTHUMP00000164735 antibody
      • OTTHUMP00000164738 antibody
      • PDGB antibody
      • PKGB antibody
      • PLAK_HUMAN antibody
      • PLAKOGLOBIN antibody
      see all

    Images

    • All lanes : Anti-gamma Catenin antibody (ab134558) at 0.1 µg/ml

      Lane 1 : Whole cell lysate from HeLa cells at 50 µg
      Lane 2 : Whole cell lysate from HeLa cells at 15 µg
      Lane 3 : Whole cell lysate from 293T cells at 50 µg
      Lane 4 : Whole cell lysate from Jurkat cells at 50 µg

      Developed using the ECL technique.

      Predicted band size: 82 kDa


      Exposure time: 3 minutes

    References

    This product has been referenced in:

    • Cooksley-Decasper S  et al. Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis. PLoS One 7:e47985 (2012). WB . Read more (PubMed: 23110151) »
    See 1 Publication for this product

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