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    gamma-catenin-phospho-y550-antibody-ab29041.pdf

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Signal Transduction Cytoskeleton / ECM Cytoskeleton Microfilaments Actin etc Catenins
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Anti-gamma Catenin (phospho Y550) antibody (ab29041)

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Western blot - Anti-gamma Catenin (phospho Y550) antibody (ab29041)

    Key features and details

    • Rabbit polyclonal to gamma Catenin (phospho Y550)
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

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    Recombinant Human gamma Catenin protein (ab114407)
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    Anti-TLX1 antibody (ab78498)

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    Overview

    • Product name

      Anti-gamma Catenin (phospho Y550) antibody
      See all gamma Catenin primary antibodies
    • Description

      Rabbit polyclonal to gamma Catenin (phospho Y550)
    • Host species

      Rabbit
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Synthetic peptide corresponding to Human gamma Catenin (phospho Y550) conjugated to keyhole limpet haemocyanin.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      Preservative: 0.05% Sodium azide
      Constituents: PBS, 50% Glycerol, 0.1% BSA
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Purification notes

      ab29041 was cross adsorbed to both phospho tyrosine coupled to agarose and to dephosphorylated gamma Catenin (Tyr550) peptide before immunogen affinity purification (without carrier protein).
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Cytoskeleton / ECM
      • Cytoskeleton
      • Microfilaments
      • Actin etc
      • Catenins

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human gamma Catenin protein (ab114407)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab29041 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    1/1000. Predicted molecular weight: 80 kDa.

    In 5% non fat milk, PBS, 0.04% Tween 20 for 1hour at room temperature.

    Notes
    WB
    1/1000. Predicted molecular weight: 80 kDa.

    In 5% non fat milk, PBS, 0.04% Tween 20 for 1hour at room temperature.

    Target

    • Function

      Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
    • Involvement in disease

      Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.
      Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
    • Sequence similarities

      Belongs to the beta-catenin family.
      Contains 9 ARM repeats.
    • Cellular localization

      Cell junction > adherens junction. Cell junction > desmosome. Cytoplasm > cytoskeleton. Membrane. Cytoplasmic in a soluble and membrane-associated form.
    • Target information above from: UniProt accession P14923 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 3728 Human
      • Omim: 173325 Human
      • SwissProt: P14923 Human
      • Unigene: 514174 Human
      • Alternative names

        • ARVD 12 antibody
        • ARVD12 antibody
        • Catenin (cadherin associated protein), gamma 80kDa antibody
        • catenin (cadherin-associated protein) gamma (80kD) antibody
        • Catenin gamma antibody
        • CTNNG antibody
        • Desmoplakin 3 antibody
        • Desmoplakin III antibody
        • Desmoplakin-3 antibody
        • Desmoplakin3 antibody
        • DesmoplakinIII antibody
        • DP 3 antibody
        • DP III antibody
        • DP3 antibody
        • DPIII antibody
        • gamma catenin antibody
        • Junction plakoglobin antibody
        • JUP antibody
        • OTTHUMP00000164732 antibody
        • OTTHUMP00000164735 antibody
        • OTTHUMP00000164738 antibody
        • PDGB antibody
        • PKGB antibody
        • PLAK_HUMAN antibody
        • PLAKOGLOBIN antibody
        see all

      Images

      • Western blot - Anti-gamma Catenin (phospho Y550) antibody (ab29041)
        Western blot - Anti-gamma Catenin (phospho Y550) antibody (ab29041)
        Western blot analysis of gamma-Catenin immunoprecipitated from lysates prepared from A431 cells treated with pervanadate. The immunoprecipitation was performed using mouse monoclonal anti-gamma-Catenin. The blots were probed with anti-phospho-gamma-Catenin (Tyr-550) antibody. The immunoprecipitated gamma-Catenin was untreated (lane 1) or treated with alkaline phosphatase (lane 2) then probed with the antibody. In addition, the anti-phospho-gamma-Catenin (Tyr-550) was used in the presence of phospho-gamma-Catenin (Tyr-550) peptide (lane 3) or phospho-gamma-Catenin (Tyr-644) peptide (lane 4).

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet download

        Download

      References (0)

      Publishing research using ab29041? Please let us know so that we can cite the reference in this datasheet.

      ab29041 has not yet been referenced specifically in any publications.

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