Product namegamma-DGG (gamma-D-Glutamylglycine), Ionotropic glutamate antagonist
DescriptionIonotropic glutamate antagonist. Low affinity AMPA antagonist.
Biological descriptionIonotropic glutamate receptor antagonist that has been used as a rapidly dissociating, low affinity competitive antagonist at AMPA receptors.
Also available in simple stock solutions (ab146702) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name(R)-4-(Carboxymethylcarbamoyl)-2-aminobutanoic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Broad spectrum / non-selective
This product has been referenced in:
- Wadiche JI & Jahr CE Multivesicular release at climbing fiber-Purkinje cell synapses. Neuron 32:301-13 (2001). Read more (PubMed: 11683999) »
- Liu G et al. Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron 22:395-409 (1999). Read more (PubMed: 10069344) »
- Watkins JC et al. Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Adv Exp Med Biol 268:49-55 (1990). Read more (PubMed: 1963751) »