Recombinant Anti-gamma H2A.X (phospho S139) antibody [EP854(2)Y] - ChIP Grade (ab81299)

Publishing research using ab81299? Please let us know so that we can cite the reference in this datasheet.

ab81299 has been referenced in 55 publications.

  • Mangeot PE  et al. Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins. Nat Commun 10:45 (2019). PubMed: 30604748
  • Saccà CD  et al. Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1a-dependent pathway. Biochim Biophys Acta Gene Regul Mech 1862:535-546 (2019). PubMed: 30951900
  • Ao Y  et al. Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model. Sci Adv 5:eaav5078 (2019). PubMed: 30906869
  • Quan Wang J  et al. Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin. J Enzyme Inhib Med Chem 33:1199-1211 (2018). PubMed: 30132373
  • Zhou R  et al. Characterization of H3 methylation in regulating oocyte development in cyprinid fish. Sci China Life Sci N/A:N/A (2018). PubMed: 30443860
  • Dos Santos M  et al. Development of whole brain versus targeted dentate gyrus irradiation model to explain low to moderate doses of exposure effects in mice. Sci Rep 8:17262 (2018). PubMed: 30467388
  • Marques-Torrejon MA  et al. Modelling glioblastoma tumour-host cell interactions using adult brain organotypic slice co-culture. Dis Model Mech 11:N/A (2018). PubMed: 29196443
  • Wang X  et al. LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation. Cell Cycle 17:439-447 (2018). PubMed: 29527968
  • Li G  et al. Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461. J Exp Clin Cancer Res 37:78 (2018). PubMed: 29631594
  • Qian M  et al. Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. Elife 7:N/A (2018). PubMed: 29717979
  • Kwasna D  et al. Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. Mol Cell 70:150-164.e6 (2018). PubMed: 29576527
  • Liu S & Liu B Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway. Med Sci Monit 24:1424-1433 (2018). PubMed: 29519997
  • Schrank BR  et al. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature 559:61-66 (2018). PubMed: 29925947
  • Luczak MW & Zhitkovich A Monoubiquitinated ?-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks. Toxicol Appl Pharmacol 355:238-246 (2018). PubMed: 30006243
  • Prasad CB  et al. Olaparib modulates DNA repair efficiency, sensitizes cervical cancer cells to cisplatin and exhibits anti-metastatic property. Sci Rep 7:12876 (2017). PubMed: 28993682
  • Peng C  et al. Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8. Sci Rep 7:4186 (2017). WB, IHC . PubMed: 28646235
  • Liu CW  et al. Histone Methyltransferase G9a Drives Chemotherapy Resistance by Regulating the Glutamate-Cysteine Ligase Catalytic Subunit in Head and Neck Squamous Cell Carcinoma. Mol Cancer Ther 16:1421-1434 (2017). PubMed: 28265008
  • Chang EY  et al. RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability. J Cell Biol 216:3991-4005 (2017). PubMed: 29042409
  • Biehs R  et al. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Mol Cell 65:671-684.e5 (2017). PubMed: 28132842
  • Cheng X  et al. Enhanced Radiotherapy using Bismuth Sulfide Nanoagents Combined with Photo-thermal Treatment. Theranostics 7:4087-4098 (2017). PubMed: 29158812
  • He H  et al. ATM mediates DAB2IP-deficient bladder cancer cell resistance to ionizing radiation through the p38MAPK and NF-?B signaling pathway. Mol Med Rep 16:1216-1222 (2017). PubMed: 28586028
  • Chu YW  et al. The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes. J Biomed Sci 24:55 (2017). PubMed: 28810862
  • Seiwert N  et al. AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells. Cell Death Dis 8:e3019 (2017). PubMed: 28837154
  • Wiedemann EM  et al. DNA Replication Origins in Immunoglobulin Switch Regions Regulate Class Switch Recombination in an R-Loop-Dependent Manner. Cell Rep 17:2927-2942 (2016). PubMed: 27974207
  • Cristini A  et al. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res 44:1161-78 (2016). ChIP . PubMed: 26578593
  • Penterling C  et al. Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. PLoS One 11:e0156599 (2016). IF . PubMed: 27253695
  • Gu X  et al. AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma. Blood 127:102-12 (2016). Flow Cyt ; Mouse . PubMed: 26385350
  • Raschke S  et al. Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams. Sci Rep 6:32441 (2016). ICC/IF ; Human . PubMed: 27578260
  • Mimmler M  et al. DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP. Nucleic Acids Res 44:10259-10276 (2016). PubMed: 27599846
  • Zhang Y  et al. Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol 23:522-30 (2016). PubMed: 27111890
  • Baldeyron C  et al. TIPIN depletion leads to apoptosis in breast cancer cells. Mol Oncol 9:1580-98 (2015). PubMed: 26004086
  • Cremaschi P  et al. Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells. PLoS One 10:e0130561 (2015). WB ; Human . PubMed: 26151554
  • Morozumi Y  et al. Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells. J Mol Cell Biol : (2015). PubMed: 26459632
  • Hu JL  et al. Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma. Int J Endocrinol 2015:136810 (2015). IHC ; Human . PubMed: 25861265
  • Sun JD  et al. Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer. Cancer Biol Ther 16:438-49 (2015). IHC . PubMed: 25679067
  • Koh CM  et al. Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest 125:2109-22 (2015). WB ; Human . PubMed: 25893605
  • Shkedy D  et al. Regulation of Elg1 activity by phosphorylation. Cell Cycle 14:3689-97 (2015). PubMed: 26177013
  • Xie C  et al. Expression of ?H2AX in various gastric pathologies and its association with Helicobacter pylori infection. Oncol Lett 7:159-163 (2014). IHC ; Human . PubMed: 24348841
  • Ha GH  et al. TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition. Oncogene 0:N/A (2014). Human . PubMed: 24769898
  • Dulev S  et al. SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1. EMBO Rep N/A:N/A (2014). WB, ICC/IF . PubMed: 25252681
  • Wu RT  et al. Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. J Biol Chem 289:34378-88 (2014). PubMed: 25336634
  • Driscoll DL  et al. Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines. PLoS One 9:e111060 (2014). IHC-P ; Mouse . PubMed: 25365521
  • Wartlick F  et al. DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac. Biochim Biophys Acta 1833:3093-3103 (2013). Human . PubMed: 23999236
  • Geuting V  et al. ATM release at resected double-strand breaks provides heterochromatin reconstitution to facilitate homologous recombination. PLoS Genet 9:e1003667 (2013). ICC/IF ; Human . PubMed: 23935532
  • Tsunoda S  et al. Differential responses of SOD1-deficient mouse embryonic fibroblasts to oxygen concentrations. Arch Biochem Biophys 537:5-11 (2013). Mouse . PubMed: 23811199
  • Yajima H  et al. The complexity of DNA double strand breaks is a critical factor enhancing end-resection. DNA Repair (Amst) 12:936-46 (2013). WB, ICC/IF ; Mouse, Human . PubMed: 24041488
  • Heylmann D  et al. Human CD4+CD25+ regulatory T cells are sensitive to low dose cyclophosphamide: implications for the immune response. PLoS One 8:e83384 (2013). ICC/IF . PubMed: 24376696
  • Ge H  et al. Dexamethasone reduces sensitivity to cisplatin by blunting p53-dependent cellular senescence in non-small cell lung cancer. PLoS One 7:e51821 (2012). ICC/IF ; Human . PubMed: 23272171
  • Lou S  et al. Human parvovirus b19 DNA replication induces a DNA damage response that is dispensable for cell cycle arrest at phase g2/m. J Virol 86:10748-58 (2012). PubMed: 22837195
  • Gaucher J  et al. Bromodomain-dependent stage-specific male genome programming by Brdt. EMBO J 31:3809-20 (2012). PubMed: 22922464
  • Sun X  et al. Identification and Characterization of a Small Inhibitory Peptide That Can Target DNA-PKcs Autophosphorylation and Increase Tumor Radiosensitivity. Int J Radiat Oncol Biol Phys : (2012). PubMed: 22592045
  • Massip L  et al. Deciphering the chromatin landscape induced around DNA double strand breaks. Cell Cycle 9:2963-72 (2010). ICC/IF . PubMed: 20714222
  • Iacovoni JS  et al. High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J 29:1446-57 (2010). PubMed: 20360682
  • Jäämaa S  et al. DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue. Cancer Res 70:8630-41 (2010). PubMed: 20978201
  • Schmid U  et al. Angiotensin II induces DNA damage in the kidney. Cancer Res 68:9239-46 (2008). PubMed: 19010896

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