gamma-Rubromycin, HIV-1 reverse transcriptase inhibitor (ab144350)

Overview

  • Product name

    gamma-Rubromycin, HIV-1 reverse transcriptase inhibitor
  • Description

    Selective, reversible HIV-1 reverse transcriptase inhibitor. Telomerase inhibitor.
  • Biological description

    Selective, reversible HIV-1 reverse transcriptase inhibitor. Shows equipotent template:primer competitive, TTP non-competitive RT inhibition as β-Rubromycin (ab144349). Telomerase inhibitor (IC50 = 3 μM, human telomerase). Shows antibacterial and cytostatic effects.
  • Purity

    > 98%
  • CAS Number

    27267-71-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Harunari E  et al. Hyaluromycin, a new hyaluronidase inhibitor of polyketide origin from marine Streptomyces sp. Mar Drugs 12:491-507 (2014). Read more (PubMed: 24451191) »
  • Wilsdorf M & Reissig HU A convergent total synthesis of the telomerase inhibitor (±)-?-rubromycin. Angew Chem Int Ed Engl 53:4332-6 (2014). Read more (PubMed: 24623604) »
  • Ueno T  et al. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. Biochemistry 39:5995-6002 (2000). Read more (PubMed: 10821671) »

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