Product nameγ–Secretase Inhibitor I
Chemical nameZ-Leu-Leu-Nle-CHO (Nle = Norleucine)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Na T et al. The notch signaling regulates CD105 expression, osteogenic differentiation and immunomodulation of human umbilical cord mesenchymal stem cells. PLoS One 10:e0118168 (2015). Read more (PubMed: 25692676) »
- Yang L et al. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget 6:14953-69 (2015). Read more (PubMed: 25879451) »
- Lee HW et al. Targeting Notch signaling by ?-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer. Clin Exp Metastasis 32:593-603 (2015). Read more (PubMed: 26134677) »
- Meng X et al. GSI-I (Z-LLNle-CHO) inhibits ?-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia 25:1135-46 (2011). Read more (PubMed: 21494254) »