Overview

  • Product name

    gamma-Tocotrienol, Form of vitamin E
  • Description

    Form of vitamin E. Antioxidant agent.
  • Biological description

    Form of vitamin E. Antioxidant agent. Tocotrienol α (ab144451), β (ab145176) and δ (ab144449) analog. Induces apoptosis in cancer cells. Shows antitumor and antihypertensive effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    14101-61-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R)-2,7,8-Trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
  • Molecular weight

    410.64
  • Molecular formula

    C28H42O2
  • PubChem identifier

    5282349
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C=C2CC[C@@](OC2=C1C)(C)CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Xiong A  et al. Elimination of ALDH+ breast tumor initiating cells by docosahexanoic acid and/or gamma tocotrienol through SHP-1 inhibition of Stat3 signaling. Mol Carcinog : (2015). Read more (PubMed: 25648304) »
  • Zhao L  et al. Activation of autophagy and AMPK by gamma-tocotrienol suppresses the adipogenesis in human adipose derived stem cells. Mol Nutr Food Res 58:569-79 (2014). Read more (PubMed: 24668775) »
  • Kunnumakkara AB  et al. {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer Res 70:8695-705 (2010). Read more (PubMed: 20864511) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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