Overview

  • Product name
    Ganciclovir (GCV), Anti-viral compound
  • Description
    Anti-viral compound. Inhibits DNA replication.
  • Biological description
    Anti-viral compound. Inhibits viral replication by competitively inhibiting incorporation of dGTP into viral DNA. Active in vivo.
  • Purity
    > 99%
  • CAS Number
    82410-32-0
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Ishiwata Y  et al. Effects of acute renal failure and ganciclovir on the pharmacodynamics of levofloxacin-induced seizures in rats. Biol Pharm Bull 30:745-50 (2007). Read more (PubMed: 17409514) »
  • Tseng JC  et al. Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PET. J Nucl Med 47:1136-43 (2006). Read more (PubMed: 16818948) »
  • Tomicic MT  et al. Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation. Oncogene 21:2141-53 (2002). Read more (PubMed: 11948397) »

Customer reviews and Q&As

Answer

This product is sold as 250 mg or 50 mg.

It is sold in a solid form and therefore needs to be dissolved. We recommend dissolving in DMSO.

Depending on what you are going to be using this product in, this will dictate what stock concentration you wish to make therefore I cannot tell you how much volume to add as I do not know what stock solution is needed for your experiment.

We state that this product is "Soluble in DMSO to 50 mM". This means that the most concentrated stock solution you can make of this product in DMSO is 50 mM. If you try to make the solution more concentrated, Ganciclover simply will not dissolve anymore in DMSO.

For example if you wanted to dissolve 50 mg in DMSO to make 50 mM, you would need to add 3918 µl of DMSO. (This is based on a molecular weight of 255.23 which will differ depending on what batch you get so will need to be recalculated.)

Depending on the batch you receive, the molecular weight of the product indicated will vary slightly depending on the number of water molecules attached. Please check the CoA of your particular batch. This document is readily downloadable from the datasheet on our website.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"
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