Overview

  • Product name
    Anti-Ganglioside asialo GM2 antibody
  • Description
    Rabbit polyclonal to Ganglioside asialo GM2
  • Host species
    Rabbit
  • Specificity
    No cross-reaction with other carbohydrate epitopes.
  • Tested applications
    Suitable for: WB, ELISA, Thin Layer Chromatographymore details
  • Species reactivity
    Reacts with a wide range of species.
  • Immunogen

    Purified ganglioside asialo GM2 and complete Freunds adjuvant (Human).

  • General notes


    This product is a mix of IgG and IgM.

Properties

Applications

Our Abpromise guarantee covers the use of ab23942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 1 kDa.
ELISA 1/1600.
Thin Layer Chromatography 1/100.

Phosphate buffered saline (pH 7.4) is the recommended diluent.

Target

  • Relevance
    Ganglioside is a compound composed of lipid and carbohydrate (glycosphingolipids) that is produced as a component of the plasma membrane of many kinds of cells. It is a component of cells found in nerve tissue endings and function in nerve impulse transmission. If these are not degenerated by enzymes, they can build up and cause brain and nerve cell damage.
  • Cellular localization
    Plasma membrane and Secreted
  • Alternative names
    • Asialo GM 2 antibody
    • Asialo GM 2 ganglioside antibody
    • Asialo GM2 antibody
    • Asialo GM2 ganglioside antibody
    • Ganglioside asialo GM 2 antibody
    see all

References

This product has been referenced in:
  • Alvarez AR  et al. Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease. FASEB J : (2008). Read more (PubMed: 18591368) »
See 1 Publication for this product

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A

Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (Brain and Liver)
Permeabilization
Yes - Hydrogen peroxide-10min
Specification
Brain and Liver
Blocking step
ab64260 protein block reagent as blocking agent for 10 minute(s) · Concentration: 5% · Temperature: RT°C
Fixative
Paraformaldehyde

Abcam user community

Verified customer

Submitted Sep 19 2016

Question
Answer

Thank you for your recent telephone enquiry.

I have now received in formation to confirm thatthe anti-asialo GM2 antibody ab23942 does not react with monosialo-GM2.

I am sorry this is not better news for you and this product would not meet your requirements on this occasion. if you have any further questions, please do not hesitate to contact us.

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Answer

I'm afraid we were unable to reach the laboratory that tested the antibody ab23942 to find out what tissues were used. However, I believe that Ganglioside asialo GM2 is a compound that is conserved in all species, of sequence GgOse3Cer; ß-GalNAc-(1?4)-ß-Gal-(1?4)-ß-Glc-(1?1')-Cer and of formula C56H104N2O18, I'm sorry I was unable to help you more in this occasion,

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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