DescriptionDownstream Hh signaling inhibitor
Biological descriptionInhibits Hh signaling downstream of smo and sufu. IC50 = 5 μM for glioma associated oncogene expression in MEFs.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM (with warming) and in ethanol to 25 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Research Area
- Alzheimer's Disease
- Signal transduction
- Hedgehog signaling
This product has been referenced in:
- Stanton BZ & Peng LF Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst 6:44-54 (2010). Read more (PubMed: 20024066) »
- Katoh Y & Katoh M Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med 9:873-86 (2009). Read more (PubMed: 19860666) »
- Lauth M et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A 104:8455-60 (2007). Read more (PubMed: 17494766) »