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  1. Link

    gardiquimod-toll-like-receptor-7-tlr7-agonist-ab141485.pdf

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Immunology Innate Immunity TLR Signaling
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Gardiquimod, toll-like receptor 7 (TLR7) agonist (ab141485)

  • Datasheet
  • SDS
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  • Datasheet
  • References

Overview

  • Product name

    Gardiquimod, toll-like receptor 7 (TLR7) agonist
  • Description

    Selective toll-like receptor 7 (TLR7) agonist
  • Biological description

    Selective TLR7 agonist. Inhibits HIV-1 reverse transcriptase. Induces pro-inflammatory cytokine production in thymocytes. Antiproliferative effects. Shows immunomodulatory effects in vivo. More active than Imiquimod (ab141410).
  • Purity

    > 98%
  • CAS Number

    1020412-43-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[4-Amino-2-(ethylaminomethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
  • Molecular weight

    313.40
  • Molecular formula

    C17H23N5O
  • PubChem identifier

    44592366
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N
  • Source

    Synthetic

  • Research areas

    • Immunology
    • Innate Immunity
    • TLR Signaling
    • Biochemicals
    • Product Range
    • New
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Toll-like Receptors
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Other
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Antiviral

Datasheets and documents

    • Datasheet
    • SDS
  • References

    This product has been referenced in:

    • Buitendijk M  et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses 29:907-18 (2013). Read more (PubMed: 23316755) »
    • Zhou Y  et al. [Inhibitory effect of toll-like receptor 7 agonist on K562 cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 20:579-82 (2012). Read more (PubMed: 22739159) »
    • Tian X  et al. Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria. PLoS One 7:e41879 (2012). Read more (PubMed: 22962579) »

    Publishing research using ab141485? Please let us know so that we can cite the reference in this datasheet.

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