• Product name
  • Description
    Rabbit polyclonal to GAS2
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Horse, Cow, Macaque monkey, Gorilla
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 50 - 150 of Human GAS2.

  • Positive control
    • This antibody gave a positive signal in Human and Mouse Kidney tissue lysate as well as both HEK293 and HepG2 whole cell lysate.


  • Form
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: PBS
    Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab106505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa).


  • Function
    May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.
  • Tissue specificity
    Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
  • Sequence similarities
    Belongs to the GAS2 family.
    Contains 1 CH (calponin-homology) domain.
    Contains 1 GAR domain.
  • Developmental stage
    Specifically expressed at growth arrest.
  • Post-translational
    Cleaved, during apoptosis, on a specific aspartic residue by caspases.
    Phosphorylated on serine residues during the G0-G1 transition phase.
  • Cellular localization
    Cytoplasm > cytoskeleton. Membrane. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.
  • Information by UniProt
  • Database links
  • Alternative names
    • GAS 2 antibody
    • GAS-2 antibody
    • Gas2 antibody
    • GAS2_HUMAN antibody
    • Growth arrest specific 2 antibody
    • Growth arrest specific protein 2 antibody
    • Growth arrest-specific protein 2 antibody
    • MGC32610 antibody
    see all


  • All lanes : Anti-GAS2 antibody (ab106505) at 1 µg/ml

    Lane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate
    Lane 2 : Human kidney tissue lysate - total protein (ab30203)
    Lane 3 : Kidney (Mouse) Tissue Lysate
    Lane 4 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 35 kDa
    Observed band size: 35 kDa
    Additional bands at: 73 kDa, 89 kDa. We are unsure as to the identity of these extra bands.

    Exposure time: 2 minutes

    In Human adult liver, lung, kidney and fetal liver tissue lysates we see a much stronger band at 73kDa. Abcam are currently unsure about the identity of this band and would welcome feedback from customers working on this protein.


ab106505 has not yet been referenced specifically in any publications.

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