• Product name

    Anti-GAS2 antibody [EPR1742(2)]
    See all GAS2 primary antibodies
  • Description

    Rabbit monoclonal [EPR1742(2)] to GAS2
  • Host species

  • Tested applications

    Suitable for: WB, IP, IHC-Pmore details
    Unsuitable for: Flow Cyt or ICC
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human GAS2 aa 1-100 (N terminal). The exact sequence is proprietary.

  • Positive control

    • HepG2, fetal liver, fetal kidney, and Jurkat lysates, Human stomach tissue
  • General notes

    Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab109762 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa).
IP 1/10 - 1/100.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
  • Application notes
    Is unsuitable for Flow Cyt or ICC.
  • Target

    • Function

      May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.
    • Tissue specificity

      Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
    • Sequence similarities

      Belongs to the GAS2 family.
      Contains 1 CH (calponin-homology) domain.
      Contains 1 GAR domain.
    • Developmental stage

      Specifically expressed at growth arrest.
    • Post-translational

      Cleaved, during apoptosis, on a specific aspartic residue by caspases.
      Phosphorylated on serine residues during the G0-G1 transition phase.
    • Cellular localization

      Cytoplasm > cytoskeleton. Membrane. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.
    • Information by UniProt
    • Database links

    • Alternative names

      • GAS 2 antibody
      • GAS-2 antibody
      • Gas2 antibody
      • GAS2_HUMAN antibody
      • Growth arrest specific 2 antibody
      • Growth arrest specific protein 2 antibody
      • Growth arrest-specific protein 2 antibody
      • MGC32610 antibody
      see all


    • All lanes : Anti-GAS2 antibody [EPR1742(2)] (ab109762) at 1/1000 dilution

      Lane 1 : HepG2 lysate
      Lane 2 : Human fetal liver lysate
      Lane 3 : Human fetal kidney lysate
      Lane 4 : Jurkat lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 35 kDa
      Observed band size: 35 kDa

    • Immunohistochemical analysis of paraffin-embedded Human stomach tissue using ab109762 at a dilution of 1/50.


    This product has been referenced in:

    • Shukla S  et al. Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer Cell 32:792-806.e7 (2017). Read more (PubMed: 29153843) »
    • Sun L  et al. GAS2-Calpain2 axis contributes to the growth of leukemic cells. Acta Biochim Biophys Sin (Shanghai) 47:795-804 (2015). Read more (PubMed: 26358320) »
    See all 2 Publications for this product

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