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    gas41-antibody-ab205018.pdf

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Epigenetics and Nuclear Signaling Transcription Other factors
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Anti-GAS41 antibody (ab205018)

  • Datasheet
Reviews (1) Submit a question References (1)

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Western blot - Anti-GAS41 antibody (ab205018)
  • Immunoprecipitation - Anti-GAS41 antibody (ab205018)

Key features and details

  • Rabbit polyclonal to GAS41
  • Suitable for: IP, WB
  • Reacts with: Human
  • Isotype: IgG

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Primary
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Anti-Cdk4 antibody [EPR4513-32-7] (ab108357)
Protein
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Recombinant Human GAS41 protein (ab116188)
Secondary
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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-GAS41 antibody
    See all GAS41 primary antibodies
  • Description

    Rabbit polyclonal to GAS41
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IP, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Cynomolgus monkey, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide within Human GAS41 aa 150 to the C-terminus. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. (NP_006521.1).
    Database link: O95619

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • Hela, Jurkat and 293T whole cell lysates.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7
    Preservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate

    pH 7 to 8
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Epigenetics and Nuclear Signaling
    • Transcription
    • Other factors
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Transcription Factors

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa whole cell lysate (ab150035)
    • HeLa whole cell lysate (ab29545)
    • Jurkat whole cell lysate (ab30128)
    • Jurkat whole cell lysate (ab7899)
  • Recombinant Protein

    • Recombinant Human GAS41 protein (ab116188)
  • Related Products

    • Recombinant Human GAS41 protein (ab116188)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab205018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
Use at 2-10 µg/mg of lysate.
WB (1)
1/2000 - 1/10000. Predicted molecular weight: 26 kDa.
Notes
IP
Use at 2-10 µg/mg of lysate.
WB
1/2000 - 1/10000. Predicted molecular weight: 26 kDa.

Target

  • Function

    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
  • Tissue specificity

    Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
  • Sequence similarities

    Contains 1 YEATS domain.
  • Cellular localization

    Nucleus.
  • Target information above from: UniProt accession O95619 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 8089 Human
    • Omim: 602116 Human
    • SwissProt: O95619 Human
    • Unigene: 4029 Human
    • Alternative names

      • 4930573H17Rik antibody
      • B230215M10Rik antibody
      • GAS 41 antibody
      • Gas41 antibody
      • glioma amplified sequence 41 antibody
      • Glioma-amplified sequence 41 antibody
      • glioma-amplified sequence-41 antibody
      • gliomaamplified sequence 41 antibody
      • gliomaamplified sequence41 antibody
      • NUBI 1 antibody
      • NuBI-1 antibody
      • NuBI1 antibody
      • NuMA binding protein 1 antibody
      • NuMA-binding protein 1 antibody
      • YAF9 antibody
      • YEATS domain containing 4 antibody
      • YEATS domain containing4 antibody
      • YEATS domain-containing protein 4 antibody
      • YEATS4 antibody
      • YETS4_HUMAN antibody
      see all

    Images

    • Western blot - Anti-GAS41 antibody (ab205018)
      Western blot - Anti-GAS41 antibody (ab205018)
      All lanes : Anti-GAS41 antibody (ab205018) at 0.1 µg/ml

      Lane 1 : Hela whole cell lysate
      Lane 2 : 293T whole cell lysate
      Lane 3 : Jurkat whole cell lysate

      Lysates/proteins at 50 µg per lane.

      Developed using the ECL technique.

      Predicted band size: 26 kDa


      Exposure time: 30 seconds


      Lysates prepared using NETN lysis buffer.

    • Immunoprecipitation - Anti-GAS41 antibody (ab205018)
      Immunoprecipitation - Anti-GAS41 antibody (ab205018)

      Detection of GAS41 in Immunoprecipitates of 293T whole cell lysates prepared using NETN lysis buffer (1 mg for IP, 20% of IP loaded) using ab205018 at 6 µg/mg lysate for IP (Lane 1) and at 1 µg/ml for subsequent Western blot detection.  Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.

    Protocols

    • Western blot protocols
    • Immunoprecipitation protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (1)

    Publishing research using ab205018? Please let us know so that we can cite the reference in this datasheet.

    ab205018 has been referenced in 1 publication.

    • Ji S  et al. YEATS Domain Containing 4 Promotes Gastric Cancer Cell Proliferation and Mediates Tumor Progression via Activating the Wnt/ß-Catenin Signaling Pathway. Oncol Res 25:1633-1641 (2017). PubMed: 28251887

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Western blot abreview for Anti-GAS41 antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Western blot
    Sample
    Chicken Cell lysate - whole cell (Chicken B-Cells)
    Gel Running Conditions
    Reduced Denaturing (Gradient (4-12%))
    Loading amount
    10 µg
    Specification
    Chicken B-Cells
    Blocking step
    Milk as blocking agent for 2 hour(s) and 30 minute(s) · Concentration: 5% · Temperature: RT°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Dr. Swagata Roy

    Verified customer

    Submitted Jan 12 2020

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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