Overview

  • Product name

  • Description

    Rabbit polyclonal to GAS41
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IP, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Cynomolgus monkey, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide within Human GAS41 aa 177-227. The exact sequence is proprietary. (NP_006521.1).
    Sequence:

    VKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQAKD I


    Database link: O95619

  • Positive control

    • Hela, Jurkat and 293T whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab205018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
WB 1/2000 - 1/10000. Predicted molecular weight: 26 kDa.

Target

  • Function

    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
  • Tissue specificity

    Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
  • Sequence similarities

    Contains 1 YEATS domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • 4930573H17Rik antibody
    • B230215M10Rik antibody
    • GAS 41 antibody
    • Gas41 antibody
    • glioma amplified sequence 41 antibody
    • Glioma-amplified sequence 41 antibody
    • glioma-amplified sequence-41 antibody
    • gliomaamplified sequence 41 antibody
    • gliomaamplified sequence41 antibody
    • NUBI 1 antibody
    • NuBI-1 antibody
    • NuBI1 antibody
    • NuMA binding protein 1 antibody
    • NuMA-binding protein 1 antibody
    • YAF9 antibody
    • YEATS domain containing 4 antibody
    • YEATS domain containing4 antibody
    • YEATS domain-containing protein 4 antibody
    • YEATS4 antibody
    • YETS4_HUMAN antibody
    see all

Images

  • All lanes : Anti-GAS41 antibody (ab205018) at 0.1 µg/ml

    Lane 1 : Hela whole cell lysate
    Lane 2 : 293T whole cell lysate
    Lane 3 : Jurkat whole cell lysate

    Lysates/proteins at 50 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 26 kDa


    Exposure time: 30 seconds


    Lysates prepared using NETN lysis buffer.

  • Detection of GAS41 in Immunoprecipitates of 293T whole cell lysates prepared using NETN lysis buffer (1 mg for IP, 20% of IP loaded) using ab205018 at 6 µg/mg lysate for IP (Lane 1) and at 1 µg/ml for subsequent Western blot detection.  Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.

References

ab205018 has not yet been referenced specifically in any publications.

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