Overview

  • Product name

    Anti-Gastric Mucin/MUC-6 antibody
    See all Gastric Mucin/MUC-6 primary antibodies
  • Description

    Rabbit polyclonal to Gastric Mucin/MUC-6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Gastric Mucin/MUC-6.
    Database link: Q6W4X9

  • Positive control

    • HEK293T, RAW 264.7 and Rat kidney lysates.
  • General notes

    Previously labelled as Gastric Mucin.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.05% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab192318 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab192318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 257 kDa.

Target

  • Function

    May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
  • Tissue specificity

    Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
  • Sequence similarities

    Contains 1 CTCK (C-terminal cystine knot-like) domain.
    Contains 1 TIL (trypsin inhibitory-like) domain.
    Contains 3 VWFD domains.
  • Developmental stage

    Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.
  • Post-translational
    modifications

    O-glycosylated.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Gastric mucin 6 antibody
    • Gastric Mucin antibody
    • Gastric mucin-6 antibody
    • MUC 6 antibody
    • MUC-6 antibody
    • Muc6 antibody
    • MUC6 Fragment antibody
    • MUC6 mucin antibody
    • MUC6 mucin Fragment antibody
    • MUC6_HUMAN antibody
    • Mucin 6 antibody
    • Mucin 6 gastric antibody
    • Mucin 6 oligomeric mucus/gel forming antibody
    • Mucin glycoprotein Fragment antibody
    • Mucin-6 antibody
    • Secretory mucin MUC6 Fragment antibody
    see all

Images

  • All lanes : Anti-Gastric Mucin/MUC-6 antibody (ab192318)

    Lane 1 : HEK293T whole cell lysate
    Lane 2 : RAW 264.7 whole cell lysate
    Lane 3 : Rat kidney tissue lysate

    Predicted band size: 257 kDa

References

ab192318 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab192318.
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