Key features and details
- Mouse monoclonal [CLH5] to Gastric Mucin/MUC-6 - BSA and Azide free
- Suitable for: IHC-P, Flow Cyt, ICC/IF
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-Gastric Mucin/MUC-6 antibody [CLH5] - BSA and Azide free
See all Gastric Mucin/MUC-6 primary antibodies
DescriptionMouse monoclonal [CLH5] to Gastric Mucin/MUC-6 - BSA and Azide free
Tested applicationsSuitable for: IHC-P, Flow Cyt, ICC/IFmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human Gastric Mucin/MUC-6. (From Gastric Mucin tandem repeat sequence).
Database link: Q6W4X9
- Human gastric carcinoma and stomach tissues.
Previously labelled as Gastric Mucin.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferConstituent: 100% PBS
Concentration information loading...
PurityProtein G purified
Purification notesab212646 was purified from Bioreactor Concentrate by Protein A/G.
Light chain typekappa
Our Abpromise guarantee covers the use of ab212646 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 2 - 4 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
(Primary incubation for 30 minutes at RT).
|Flow Cyt||Use 1-2µg for 106 cells.
(in 0.1 ml).
|ICC/IF||Use a concentration of 1 - 2 µg/ml.|
FunctionMay provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
Tissue specificityExpressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
Sequence similaritiesContains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 TIL (trypsin inhibitory-like) domain.
Contains 3 VWFD domains.
Developmental stageEarly expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.
- Information by UniProt
- Gastric mucin 6 antibody
- Gastric Mucin antibody
- Gastric mucin-6 antibody
ab212646 has not yet been referenced specifically in any publications.