Overview

  • Product name

    Anti-Gastric Mucin/MUC-6 antibody [MUC6/916] - BSA and Azide free
    See all Gastric Mucin/MUC-6 primary antibodies
  • Description

    Mouse monoclonal [MUC6/916] to Gastric Mucin/MUC-6 - BSA and Azide free
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Does not react with: Rat
  • Immunogen

    Recombinant full length protein corresponding to Human Gastric Mucin/MUC-6.
    Database link: Q6W4X9

  • Positive control

    • Human gastric carcinoma and stomach tissues.
  • General notes

    Previously labelled as Gastric Mucin.

Properties

Applications

Our Abpromise guarantee covers the use of ab212648 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2 - 4 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

(Primary incubation for 30 minutes at RT).

Target

  • Function

    May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
  • Tissue specificity

    Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
  • Sequence similarities

    Contains 1 CTCK (C-terminal cystine knot-like) domain.
    Contains 1 TIL (trypsin inhibitory-like) domain.
    Contains 3 VWFD domains.
  • Developmental stage

    Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.
  • Post-translational
    modifications

    O-glycosylated.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Gastric mucin 6 antibody
    • Gastric Mucin antibody
    • Gastric mucin-6 antibody
    • MUC 6 antibody
    • MUC-6 antibody
    • Muc6 antibody
    • MUC6 Fragment antibody
    • MUC6 mucin antibody
    • MUC6 mucin Fragment antibody
    • MUC6_HUMAN antibody
    • Mucin 6 antibody
    • Mucin 6 gastric antibody
    • Mucin 6 oligomeric mucus/gel forming antibody
    • Mucin glycoprotein Fragment antibody
    • Mucin-6 antibody
    • Secretory mucin MUC6 Fragment antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue labeling Gastric Mucin/MUC-6 with ab212648 at 4 μg/ml dilution.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue labeling Gastric Mucin/MUC-6 with ab212648 at 4 μg/ml dilution.

References

This product has been referenced in:

  • Wei J  et al. Establishment and characterization of the GC-030-35 cell line derived from gastric hepatoid adenocarcinoma. Cancer Manag Res 11:1275-1287 (2019). Read more (PubMed: 30799954) »
See 1 Publication for this product

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