• Product name

  • Description

    Rabbit polyclonal to Gastrin
  • Host species

  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Horse, Dog
  • Immunogen

    Synthetic peptide within Human Gastrin aa 50 to the C-terminus. The exact sequence is proprietary.
    Database link: P01350

  • Positive control

    • Pituitary or stomach
  • General notes

    This antibody may be used to study the differential tissue expression and intracellular and subcellular localization of gastrin in neuroendocrine cells of the gastrointestinal tract,and in the CNS. Antibodies to gastrin are also useful for the identificationand detection of gastrin in normal and neoplastic tissue.



Our Abpromise guarantee covers the use of ab16035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200.


  • Function

    Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
  • Sequence similarities

    Belongs to the gastrin/cholecystokinin family.
  • Post-translational

    Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
    Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • Component II antibody
    • G14 antibody
    • G17 antibody
    • G34 antibody
    • G52 antibody
    • G6 antibody
    • GAS antibody
    • Gast antibody
    • GAST_HUMAN antibody
    • Gastrin antibody
    • Gastrin component I antibody
    • Gastrin component II antibody
    • Gastrin component III antibody
    • Gastrin precursor antibody
    • Gastrin-14 antibody
    • Gastrin-17 antibody
    • Gastrin-34 antibody
    • Gastrin-52 antibody
    • Gastrin-6 antibody
    • Gastrin-71 antibody
    see all


  • ab16035 staining human Gastrin at 1/200 dilution in stomach by Immunohistochemistry (FFPE-sections).


This product has been referenced in:

  • Lennerz JK  et al. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. Am J Pathol 177:1514-33 (2010). IHC-P ; Human . Read more (PubMed: 20709804) »
See 1 Publication for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A


Thank you for contacting us.

We do not have any experimental data regarding the cross-reactivity of ab16035 with CCK. I compared the immunogen sequence for ab16035 with that of the CCK sequence (P06307-Uniprot) and the percentage homology is 50%, thus it is unlikely that it will cross-react with CCK.

Please do not hesitate to contact me with additional questions or concerns.

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Thank you for contacting us.

We have not experimentally tested the possibility of ab16035 cross reactivity with CCK. So I am sorry we cannot confirm it 100%. The recommendations we gave were based on the minimal sequence homology between CCK and Gastrin. There is no sequence homology between Gastrin and CCK in the N-terminal region, so it is more likely that antibodies raised to these regions will not be cross-reacting.

The Gasrin sequence I was looking at in given at the following link; http://www.uniprot.org/uniprot/P01350 and the CCK link is http://www.uniprot.org/uniprot/P06307

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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