Key features and details
- Rabbit polyclonal to Gastrin, prediluted
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Gastrin antibody, prediluted
See all Gastrin primary antibodies
DescriptionRabbit polyclonal to Gastrin, prediluted
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Horse, Dog
Synthetic peptide within Human Gastrin aa 50 to the C-terminus. The exact sequence is proprietary.
Database link: P01350
This antibody may be used to study the differential tissue expression and intracellular and subcellular localization of gastrin in neuroendocrine cells of the gastrointestinal tract, and in the CNS. Antibodies to gastrin are also useful for the identification and detection of gastrin in normal and neoplastic tissue.
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Storage instructionsShipped at 4°C. Store at +4°C. Do Not Freeze.
Storage bufferpH: 7.60
Preservative: 0.1% Sodium azide
Constituents: Tris buffered saline, 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Primary antibody notesThis antibody may be used to study the differential tissue expression and intracellular and subcellular localization of gastrin in neuroendocrine cells of the gastrointestinal tract, and in the CNS. Antibodies to gastrin are also useful for the identification and detection of gastrin in normal and neoplastic tissue.
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab16036 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Ready to use.
Ready to use.
FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Sequence similaritiesBelongs to the gastrin/cholecystokinin family.
modificationsTwo different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
- Information by UniProt
- Component II antibody
- G14 antibody
- G17 antibody
ab16036 has not yet been referenced specifically in any publications.