Key features and details
- Rabbit polyclonal to Gastrin, prediluted
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Gastrin antibody, prediluted
See all Gastrin primary antibodies
DescriptionRabbit polyclonal to Gastrin, prediluted
Species reactivityReacts with: Human
Recombinant full length protein conjugated to KLH.
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Storage instructionsShipped at 4°C. Store at +4°C. Do Not Freeze.
Storage bufferPreservative: 0.05% Sodium azide
Concentration information loading...
PurityProtein A purified
No further titration is required.
We suggest an incubation period of 30-60 minutes at room temperature.
However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the user.
FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Sequence similaritiesBelongs to the gastrin/cholecystokinin family.
modificationsTwo different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
- Information by UniProt
- Component II antibody
- G14 antibody
- G17 antibody
ab928 has not yet been referenced specifically in any publications.