Anti-Gastrin antibody, prediluted (ab928)
Key features and details
- Rabbit polyclonal to Gastrin, prediluted
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Gastrin antibody, prediluted
See all Gastrin primary antibodies -
Description
Rabbit polyclonal to Gastrin, prediluted -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Gastrin conjugated to keyhole limpet haemocyanin.
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Positive control
- IHC-P: Human stomach tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. Do Not Freeze. -
Storage buffer
pH: 7.3
Preservative: 0.05% Sodium azide
Inert stabilizer -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Myeloma
unknown -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab928 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
1/50 - 1/100.
Incubate with primary antibody for 30 minutes at room temperature. |
Notes |
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IHC-P
1/50 - 1/100. Incubate with primary antibody for 30 minutes at room temperature. |
Target
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Function
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. -
Sequence similarities
Belongs to the gastrin/cholecystokinin family. -
Post-translational
modificationsTwo different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 2520 Human
- Omim: 137250 Human
- SwissProt: P01350 Human
- Unigene: 2681 Human
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Alternative names
- Component II antibody
- G14 antibody
- G17 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab928 has not yet been referenced specifically in any publications.