Gastrodin (Gastrodine), neuroprotective and anticonvulsant agent (ab143165)

Overview

  • Product name

    Gastrodin (Gastrodine), neuroprotective and anticonvulsant agent
  • Description

    Neuroprotective and anticonvulsant agent
  • Biological description

    Neuroprotective and anticonvulsant agent. Attenuates glutamate accumulation during cerebral ischemia. Regulates Na+ and K+ currents in small DRG neurons. Shows antidepressant, analgesic and sedative effects in vivo. Blood-brain barrier permeable. Orally active.
  • Purity

    > 99%
  • CAS Number

    62499-27-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
  • Molecular weight

    286.28
  • Molecular formula

    C13H18O7
  • PubChem identifier

    115067
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [C@@H]1([C@@H]([C@H]([C@@H](O[C@H]1CO)OC2=CC=C(C=C2)CO)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wang H  et al. Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: Involvement of its anti-inflammatory action. Behav Brain Res 266:153-60 (2014). Read more (PubMed: 24613238) »
  • Jiang G  et al. Gastrodin Inhibits Glutamate-Induced Apoptosis of PC12 Cells via Inhibition of CaMKII/ASK-1/p38 MAPK/p53 Signaling Cascade. Cell Mol Neurobiol 34:591-602 (2014). Read more (PubMed: 24619207) »
  • Cai Z  et al. Role of glucose transporters in the intestinal absorption of gastrodin, a highly water-soluble drug with good oral bioavailability. J Drug Target 21:574-80 (2013). Read more (PubMed: 23480725) »
  • Sun W  et al. Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing excitability of nociceptive primary sensory neurons. PLoS One 7:e39647 (2012). Read more (PubMed: 22761855) »
  • Yong W  et al. Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus. Planta Med 75:1112-7 (2009). Read more (PubMed: 19291610) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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