Overview

  • Product name

  • Description

    Rabbit polyclonal to GATM
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Chicken, Cow, Dog, Pig, Xenopus laevis
  • Immunogen

    Recombinant fragment within Human GATM (internal sequence). The exact sequence is proprietary.
    Database link: P50440

  • Positive control

    • WB: HepG2 whole cell lysate (ab7900), Mouse liver tissue extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab228937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 48 kDa.

Target

  • Function

    Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
  • Tissue specificity

    Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues.
  • Pathway

    Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2.
  • Involvement in disease

    Defects in GATM are the cause of arginine:glycine amidinotransferase deficiency (AGAT deficiency) [MIM:612718]. AGAT deficiency is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, and severe depletion of creatine/phosphocreatine in the brain.
  • Sequence similarities

    Belongs to the amidinotransferase family.
  • Domain

    One chain folds into a compact single domain composed of repeating units, five beta-beta-alpha-beta modules, which surround the central active site.
  • Cellular localization

    Mitochondrion inner membrane. Cytoplasm. The mitochondrial form is found in the intermembrane space probably attached to the outer side of the inner membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • AGAT antibody
    • AT antibody
    • GATM antibody
    • GATM_HUMAN antibody
    • Glycine amidinotransferase antibody
    • Glycine amidinotransferase, mitochondrial antibody
    • L-arginine:glycine amidinotransferase antibody
    • mitochondrial antibody
    • Transamidinase antibody
    see all

Images

  • Anti-GATM antibody (ab228937) at 1/500 dilution + Mouse liver tissue extracts at 50 µg

    Developed using the ECL technique.

    Predicted band size: 48 kDa



    10% SDS-PAGE

References

ab228937 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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