Overview

  • Product name

  • Description

    Rabbit polyclonal to GCDH/GCD
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, IP, WB, IHC-P, IHC-Frmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human GCDH/GCD (N terminal).

  • General notes

     This product was previously labelled as GCDH

     

Properties

Applications

Our Abpromise guarantee covers the use of ab75324 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 21163940
IP Use at an assay dependent concentration. PubMed: 21163940
WB 1/500 - 1/2000. Predicted molecular weight: 48 kDa.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

Target

  • Function

    Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.
  • Tissue specificity

    Isoform 1 and isoform 2 are expressed in fibroblasts and liver.
  • Pathway

    Amino-acid metabolism; lysine degradation.
    Amino-acid metabolism; tryptophan metabolism.
  • Involvement in disease

    Defects in GCDH are the cause of glutaric aciduria type 1 (GA1) [MIM:231670]. GA1 is an autosomal recessive metabolic disorder characterized by progressive dystonia and athetosis due to gliosis and neuronal loss in the basal ganglia.
  • Sequence similarities

    Belongs to the acyl-CoA dehydrogenase family.
  • Cellular localization

    Mitochondrion matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACAD5 antibody
    • EC 1.3.99.7 antibody
    • GCD antibody
    • Gcdh antibody
    • GCDH_HUMAN antibody
    • Glutaryl CoA dehydrogenase antibody
    • Glutaryl CoA dehydrogenase, mitochondrial antibody
    • Glutaryl Coenzyme A dehydrogenase antibody
    • Glutaryl-CoA dehydrogenase antibody
    • mitochondrial antibody
    • MS781 antibody
    see all

References

This product has been referenced in:

  • Soler-López M  et al. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. Genome Res 21:364-76 (2011). WB, ICC/IF, IP ; Human . Read more (PubMed: 21163940) »
See 1 Publication for this product

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