Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab211628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-GCLC antibody [EP13475] (ab190685)

  • Form

    Lyophilised
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names

    • EC 6.3.2.2
    • Gamma ECS
    • Gamma glutamylcysteine synthetase
    • Gamma-ECS
    • Gamma-glutamylcysteine synthetase
    • GCL
    • Gclc
    • GCS
    • GCS heavy chain
    • GLCL
    • GLCLC
    • Glutamate cysteine ligase catalytic subunit
    • Glutamate--cysteine ligase catalytic subunit
    • GSH1_HUMAN
    see all
  • Pathway

    Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
  • Involvement in disease

    Defects in GCLC are the cause of hemolytic anemia (HAGGSD) [MIM:230450].
  • Sequence similarities

    Belongs to the glutamate--cysteine ligase type 3 family.
  • Information by UniProt

References

ab211628 has not yet been referenced specifically in any publications.

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