Overview

  • Product name

    GDC-0941 dimesylate, PI3K inhibitor
  • Description

    Potent PI3K inhibitor. GDC-0941 analog.
  • Biological description

    Potent PI3K inhibitor. GDC-0941 (ab141352) analog. Putative apoptotic and antitumor agent.
  • CAS Number

    957054-33-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine di(methanesulfonate)
  • Molecular weight

    705.86
  • Molecular formula

    C23H27N7O3S2.2CH3SO3H
  • PubChem identifier

    56972143
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6.CS(=O)(=O)O.CS(=O)(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Poovassery JS  et al. Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer. Int J Cancer 137:267-77 (2015). Read more (PubMed: 25471734) »
  • Ehrhardt M  et al. The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy. Oncotarget 6:802-13 (2015). Read more (PubMed: 25596739) »
  • Wallin JJ  et al. GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death in vitro and in vivo. Clin Cancer Res 18:3901-11 (2012). Read more (PubMed: 22586300) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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