• Product name

  • Description

    Sheep polyclonal to GDNF
  • Host species

  • Specificity

    Cross reactivity: This antibody is known to react with human, mouse, rat and other rodents. Cross reactivity with other species has not been tested. No cross reactivity with NTN. GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot.
  • Tested applications

    Suitable for: Dot blot, WB, IHC (PFA fixed)more details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant human Glial Derived Neurotrophic Factor.

  • General notes

    This antibody has been used successfully for immunohistochemistry, immunoblotting and quantitative 2- site ELISA.


Associated products


Our Abpromise guarantee covers the use of ab6206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot
IHC (PFA fixed)
  • Application notes
    Dot: 1/3000.
    Immunohistochemistry (PFA fixed): Use at an assay dependent dilution on 4% paraformaldehyde perfusion fixed tissue cut on cryostat. See protocols given in the book "Neurotrophin Protocols" edited by RA Rush and published by Humana Press. This book is volume 169 in the Methods in Molecular Biology series.
    WB: 1/3000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
    • Tissue specificity

      In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
    • Involvement in disease

      Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
      Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
    • Sequence similarities

      Belongs to the TGF-beta family. GDNF subfamily.
    • Cellular localization

    • Information by UniProt
    • Database links

    • Alternative names

      • Astrocyte derived trophic factor antibody
      • Astrocyte derived trophic factor 1 antibody
      • Astrocyte-derived trophic factor antibody
      • ATF 1 antibody
      • ATF 2 antibody
      • Atf antibody
      • ATF1 antibody
      • ATF2 antibody
      • gdnf antibody
      • GDNF_HUMAN antibody
      • Glial cell derived neurotrophic factor antibody
      • Glial Cell Line Derived Neurotrophic Factor antibody
      • Glial cell line-derived neurotrophic factor antibody
      • Glial derived neurotrophic factor antibody
      • HFB1 GDNF antibody
      • hGDNF antibody
      • HSCR3 antibody
      see all


    ab6206 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As


    I am very sorry to inform you that I have been unable to find out more information regarding our GDNF antibody ab6206 regarding the protocols used to test them in IHC. The academic scientist who has tested it seems to be unavailable. From his published work it seems that his preferred method of IHC is by using perfusion fixed cryostat sections (typically with an overnight PFA fixation). I would be happy to offer you a refund if the product did not work using this method. The antibody ab6207 has not been reported to have been tested in IHC currently, while ab18956 has been only tested on fresh frozen sections currently. I am sorry I couldn't help you more on this occasion,

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