Overview

  • Product name

    Anti-GDNF Receptor alpha 2/GFRA2 antibody
    See all GDNF Receptor alpha 2/GFRA2 primary antibodies
  • Description

    Rabbit polyclonal to GDNF Receptor alpha 2/GFRA2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Horse, Cow, Dog, Chimpanzee, Rhesus monkey, Opossum, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human GDNF Receptor alpha 2/GFRA2 aa 377-391.
    Sequence:

    RVEKTPSLPDDLSDS

  • Positive control

    • HeLa whole cell lysate.
  • General notes

    Purified IgG

     This product was previously labelled as GDNF Receptor alpha 2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab62124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Detects a band of approximately 52 kDa (predicted molecular weight: 52 kDa).

Target

  • Function

    Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
    Isoform 2: Participates to NRTN-induced 'Ser-727' phosphorylation of STAT3.
  • Tissue specificity

    Isoform 1 is found in both brain and placenta.
  • Sequence similarities

    Belongs to the GDNFR family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • GDNF family receptor alpha 2 antibody
    • GDNF family receptor alpha-2 antibody
    • GDNF receptor alpha-2 antibody
    • GDNF receptor beta antibody
    • GDNFR beta antibody
    • GDNFR-alpha-2 antibody
    • GDNFR-beta antibody
    • GDNFRB antibody
    • GFR alpha 2 antibody
    • GFR-alpha-2 antibody
    • GFRA 2 antibody
    • Gfra2 antibody
    • GFRA2_HUMAN antibody
    • Glial cell line derived neurotrophic factor family receptor alpha2b antibody
    • Glial cell line derived neurotrophic factor receptor beta antibody
    • Neurturin receptor alpha antibody
    • NRTNR alpha antibody
    • NRTNR-alpha antibody
    • NTNR alpha antibody
    • NTNR-alpha antibody
    • NTNRA antibody
    • PI linked cell surface accessory protein antibody
    • PI linked cell-surface accessory protein antibody
    • RET ligand 2 antibody
    • RETL 2 antibody
    • RETL2 antibody
    • TGF beta related neurotrophic factor receptor 2 antibody
    • TGF-beta-related neurotrophic factor receptor 2 antibody
    • TRN receptor GPI anchored antibody
    • TRNR 2 antibody
    • TRNR2 antibody
    see all

Images

  • Anti-GDNF Receptor alpha 2/GFRA2 antibody (ab62124) at 1/1000 dilution + HeLa total cell lysate

    Predicted band size: 52 kDa
    Observed band size: 52 kDa

References

This product has been referenced in:

  • Zhang YP  et al. Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1ß in rats. Behav Brain Res 347:436-445 (2018). Read more (PubMed: 29580890) »
  • Luo S  et al. Effect of nutritional supplement on bone marrow-derived mesenchymal stem cells from aplastic anaemia. Br J Nutr 119:748-758 (2018). Read more (PubMed: 29569543) »
See all 2 Publications for this product

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