Geldanamycin-FITC, fluorescent labelled HSP90 inhibitor (ab141589)
Key features and details
- Potent fluorescent labelled-HSP90 inhibitor
- CAS Number: 30562-34-6
- Purity: > 98%
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Geldanamycin-FITC, fluorescent labelled HSP90 inhibitor -
Description
Potent fluorescent labelled-HSP90 inhibitor -
Biological description
Potent fluorescent labelled-HSP90 inhibitor for in vitro and in vivo use. Geldanamycin from Streptomyces hygroscopicus. -
Purity
> 98% -
CAS Number
30562-34-6 -
Chemical structure
Properties
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Molecular weight
1034.20 -
Molecular formula
C55H63N5O13S -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
NC(=O)O[C@H]1C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC=6C(=O)C(NC(=O)C(C)=CC=C[C@@H]1OC)=CC(=O)C=6NCCCCCCNC(=S)Nc5ccc(C=2c4ccc(O)cc4OC3=CC(=O)C=CC=23)c(c5)C(=O)O -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab141589 has been referenced in 5 publications.
- Pan X et al. Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy. Molecules 27:N/A (2022). PubMed: 36080326
- Li Z et al. Synthesis and biological evaluation of geldanamycin-ferulic acid conjugate as a potent Hsp90 inhibitor. RSC Adv 9:42509-42515 (2019). PubMed: 35542888
- Geng K et al. Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs. Eur J Med Chem 152:76-86 (2018). PubMed: 29698859
- Zhang C et al. Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors. Eur J Med Chem 125:315-326 (2017). PubMed: 27688186
- Li Z et al. Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors. Chem Biol Drug Des 85:181-8 (2015). PubMed: 24903735