Overview

  • Product name

    Gemcitabine, Cytidine analog
  • Description

    Cytidine analog. Antimetabolite.
  • Biological description

    Cytidine analog. Antimetabolite. Induces apoptosis. Blocks cytosine nucleotide conversion into the deoxy derivative and blocks incorporation of the thymidine nucleotide into the DNA strand. Shows antitumor effects in vivo.
  • Purity

    > 99%
  • CAS Number

    95058-81-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
  • Molecular weight

    263.20
  • Molecular formula

    C9H11F2N3O4
  • PubChem identifier

    60750
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Guillaumond F  et al. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A 112:2473-8 (2015). Read more (PubMed: 25675507) »
  • Liu WM  et al. Supernatants of tumours treated with chemotherapy can alter tumour growth and development in vivo. Anticancer Res 35:1499-508 (2015). Read more (PubMed: 25750303) »
  • Xu Y  et al. Anti-tumor effect of the extract from qingyihuaji formula on pancreatic cancer by down-regulating Notch-4 and Jagged-1. J Tradit Chin Med 35:77-83 (2015). Read more (PubMed: 25842732) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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