Overview

  • Product name

    Gemcitabine hydrochloride, Deoxycytidine analog
  • Description

    Potent, specific deoxycytidine analog
  • Alternative names

    • LY188011
  • Biological description

    Potent specific, deoxycytidine analog. Pro-drug phosphorylated by deoxycytidine kinase to gemcitabine diphosphate (dFdCDP) and triphosphate (dFdCTP). Cell cycle specific, inhibits the S and G1 phase. Antitumor activity in vitro and in vivo.
  • Purity

    > 99%
  • CAS Number

    122111-03-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Elnaggar M  et al. Molecular targets of gemcitabine action: rationale for development of novel drugs and drug combinations. Curr Pharm Des 18:2811-29 (2012). Read more (PubMed: 22390765) »
  • Heinemann V  et al. Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism. Semin Oncol 22:11-8 (1995). Read more (PubMed: 7481839) »
  • Plunkett W  et al. Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Semin Oncol 22:3-10 (1995). Read more (PubMed: 7481842) »
  • Hertel LW  et al. Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine). Cancer Res 50:4417-22 (1990). Read more (PubMed: 2364394) »

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