Geniposidic acid, anti-inflammatory and anticancer agent (ab143267)

Overview

  • Product name

    Geniposidic acid, anti-inflammatory and anticancer agent
  • Description

    Anti-inflammatory and anticancer agent
  • Biological description

    Anti-inflammatory and anticancer agent. Moderate COX inhibitor and Heat shock factor 1 inducer. Promotes collagen synthesis and shows antitumor effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    27741-01-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,4aS,7aS)-1-(β-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid
  • Molecular weight

    374.34
  • Molecular formula

    C16H22O10
  • PubChem identifier

    443354
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1O[C@H]([C@]2([C@@](C=1C(=O)O)(CC=C2CO)[H])[H])O[C@@H]3O[C@@H]([C@H]([C@@H]([C@@H]3O)O)O)CO
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Nam JW  et al. Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents. Chem Biodivers 10:1322-7 (2013). Read more (PubMed: 23847077) »
  • Carrillo-Ocampo D  et al. Anti-inflammatory activity of iridoids and verbascoside isolated from Castilleja tenuiflora. Molecules 18:12109-18 (2013). Read more (PubMed: 24084016) »
  • Park KS  et al. Inhibitory Potencies of Several Iridoids on Cyclooxygenase-1, Cyclooxygnase-2 Enzymes Activities, Tumor Necrosis factor-a and Nitric Oxide Production In Vitro. Evid Based Complement Alternat Med 7:41-5 (2010). Read more (PubMed: 18955286) »
  • Li Y  et al. The promoting effects of geniposidic acid and aucubin in Eucommia ulmoides Oliver leaves on collagen synthesis. Biol Pharm Bull 21:1306-10 (1998). Read more (PubMed: 9881644) »
  • Hsu HY  et al. Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation. Cancer Lett 113:31-7 (1997). Read more (PubMed: 9065798) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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