Overview

  • Product name

    Genistin, Isoflavone glycoside
  • Description

    Isoflavone glycoside. Inactive analog of Genistein.
  • Biological description

    Isoflavone glycoside. Inactive analog of Genistein. Glycoside of Genistein (ab120112). Selective terminal deoxyribonucleotidyltransferase inhibitor. Stimulates estrogen-dependent breast cancer cell growth in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    529-59-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Hydroxy-3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
  • Molecular weight

    432.40
  • Molecular formula

    C21H20O10
  • PubChem identifier

    5281377
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)OC4C(C(C(C(O4)CO)O)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mizushina Y  et al. Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation. Int J Oncol 43:1117-24 (2013). Read more (PubMed: 23900272) »
  • Popovic BM  et al. Enhancement of antioxidant and isoflavones concentration in gamma irradiated soybean. ScientificWorldJournal 2013:383574 (2013). Read more (PubMed: 24298214) »
  • Uchiyama Y  et al. Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin. Biochim Biophys Acta 1725:298-304 (2005). Read more (PubMed: 16099107) »
  • Allred CD  et al. Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22:1667-73 (2001). Read more (PubMed: 11577007) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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