Gentiopicroside (Gentiopicrin), Anticonvulsant agent (ab143623)

Overview

  • Product name

    Gentiopicroside (Gentiopicrin), Anticonvulsant agent
  • Description

    Anticonvulsant agent
  • Alternative names

    • Gentiopicrin
  • Biological description

    Anticonvulsant agent. Downregulates GluN2B-containing NMDA receptors in the NAc. Antiaddiction, anticonvulsant and anxiolytic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    20831-76-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,4R)-4-Ethenyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,6-dihydro-3H-pyrano[3,4-c]pyran-8-one
  • Molecular weight

    356.32
  • Molecular formula

    C16H20O9
  • PubChem identifier

    88708
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C=CC1C(OC=C2C1=CCOC2=O)OC3C(C(C(C(O3)CO)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mahendran G  et al. Evaluation of Anticonvulsant, Sedative, Anxiolytic, and Phytochemical Profile of the Methanol Extract from the Aerial Parts of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke. Biomed Res Int 2014:542385 (2014). Read more (PubMed: 24877112) »
  • Mihailovic V  et al. Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats. Food Funct : (2014). Read more (PubMed: 24912992) »
  • Liu SB  et al. Gentiopicroside attenuates morphine rewarding effect through downregulation of GluN2B receptors in nucleus accumbens. CNS Neurosci Ther 18:652-8 (2012). Read more (PubMed: 22621711) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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