Key features and details
- Mevalonate pathway intermediate; geranylgeranyl pyrophosphate precursor
- CAS Number: 24034-73-9
- Purity: > 95%
- Soluble in DMSO to 75 mM and in ethanol to 75 mM
- Form / State: Solid
- Source: Synthetic
Product nameGeranylgeraniol, geranylgeranyl pyrophosphate precursor
DescriptionMevalonate pathway intermediate; geranylgeranyl pyrophosphate precursor
Biological descriptionMevalonate pathway intermediate and geranylgeranylpyrophosphate precursor. Prevents bone re-absorption, inhibition of osteoclast formation, kinase activation and induces apoptosis in vitro. Supresses tumour cell growth in vitro. (IC50= 55 µM). Cell-permeable.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 75 mM and in ethanol to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142436 has been referenced in 1 publication.
- Balaz M et al. Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation. Cell Metab 29:901-916.e8 (2019). PubMed: 30581121