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    gfr-alpha-3gfra3-peptide-ab6100.pdf

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Neuroscience Neurology process Growth and Development Neurotrophins
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GFR alpha 3/GFRA3 peptide (ab6100)

  • Datasheet
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Key features and details

  • Suitable for: Blocking

Description

  • Product name

    GFR alpha 3/GFRA3 peptide
    See all GFR alpha 3/GFRA3 proteins and peptides
  • Animal free

    No
  • Nature

    Synthetic

Associated products

  • Related Products

    • Anti-GFR alpha 3/GFRA3 antibody (ab8028)

Specifications

Our Abpromise guarantee covers the use of ab6100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Liquid
  • Additional notes

    Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novelglycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the discovery of GFRa-1 and -2, a novel receptor in GFRa family was identified recently in human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

     This product was previously labelled as GFR alpha 3

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.1% BSA

General Info

  • Alternative names

    • GDNF family receptor alpha 3
    • GDNF family receptor alpha-3
    • GDNF receptor alpha-3
    • GDNFR-alpha-3
    • GDNFR3
    • GFR-alpha-3
    • GFRA3
    • GFRA3_HUMAN
    • Glial cell line derived neurotrophic factor receptor alpha 3
    • GPI linked receptor
    • OTTHUMP00000159486
    • OTTHUMP00000224020
    see all
  • Function

    Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
  • Tissue specificity

    Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
  • Sequence similarities

    Belongs to the GDNFR family.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession O60609 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab6100? Please let us know so that we can cite the reference in this datasheet.

ab6100 has not yet been referenced specifically in any publications.

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