Overview

  • Product name

    GGACK dihydrochloride, Urokinase inhibitor
  • Description

    Irreversible Urokinase inhibitor
  • Biological description

    Irreversible Urokinase inhibitor. Factor Xa inhibitor. Anticoagulant. Active in vitro.
  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4S)-4-Amino-5-[[2-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]acetyl]amino]-5-oxopentanoic acid dihydrochloride
  • Molecular weight

    465.76
  • Molecular formula

    C14H25ClN6O5.2HCl
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)CCl)[C@@H](N)CCC(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sperl S  et al. (4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase. Proc Natl Acad Sci U S A 97:5113-8 (2000). Read more (PubMed: 10805774) »
  • Lyon ME  et al. Evaluation of the thrombin inhibitor D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPACK) with the factor Xa inhibitor 1,5-dansyl-L-glutamyl-L-glycyl-L-arginine chloromethylketone (GGACK) as anticoagulants for critical care clinical chemistry specimens. Clin Chim Acta 280:91-9 (1999). Read more (PubMed: 10090527) »
  • Oethinger MD & Seifried E In vitro effects of urokinase--prevention by different inhibitors. Thromb Haemost 64:402-6 (1990). Read more (PubMed: 1710833) »

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