Anti-GGPS1 antibody (ab155584)
Key features and details
- Rabbit polyclonal to GGPS1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-GGPS1 antibody
See all GGPS1 primary antibodies -
Description
Rabbit polyclonal to GGPS1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow, Xenopus laevis, Xenopus tropicalis -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 105-300 of Human GGPS1 (Uniprot ID: O95749).
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Positive control
- PC3 and SK-N-SH whole cell lysates; Human BT483 xenograft tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab155584 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/5000 - 1/20000. Predicted molecular weight: 35 kDa.
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IHC-P |
1/100 - 1/1000.
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Notes |
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WB
1/5000 - 1/20000. Predicted molecular weight: 35 kDa. |
IHC-P
1/100 - 1/1000. |
Target
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Function
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. -
Tissue specificity
Abundantly expressed in testis. Found in other tissues to a lower extent. -
Pathway
Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. -
Sequence similarities
Belongs to the FPP/GGPP synthase family. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 780882 Cow
- Entrez Gene: 9453 Human
- Entrez Gene: 14593 Mouse
- Entrez Gene: 291211 Rat
- Entrez Gene: 100049104 Xenopus laevis
- Entrez Gene: 549876 Xenopus tropicalis
- Omim: 606982 Human
- SwissProt: P56966 Cow
see all -
Alternative names
- (2E antibody
- 6E)-farnesyl diphosphate synthase antibody
- Dimethylallyltranstransferase antibody
see all
Images
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All lanes : Anti-GGPS1 antibody (ab155584) at 1/10000 dilution
Lane 1 : PC3 whole cell lysate
Lane 2 : SK-N-SH whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size: 35 kDa
10% SDS PAGE -
Immunohistochemical analysis of paraffin-embedded Human BT483 xenograft tissue labeling GGPS1 with ab155584 at 1/500 dilution.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab155584 has been referenced in 1 publication.
- Wei L et al. GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism. J Biol Chem 295:15988-16001 (2020). PubMed: 32913122