• Product name

    Anti-GGT1/GGT antibody - N-terminal
    See all GGT1/GGT primary antibodies
  • Description

    Goat polyclonal to GGT1/GGT - N-terminal
  • Host species

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Monkey
  • Immunogen

    Synthetic peptide corresponding to Human GGT1/GGT aa 27-40 (N terminal) (Cysteine residue).


    Database link: P19440

  • Positive control

    • Human liver tissue. Human kidney lysate.
  • General notes

     This product was previously labelled as GGT1




Our Abpromise guarantee covers the use of ab195662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 61 kDa.
IHC-P Use a concentration of 5 µg/ml.


  • Function

    Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.
  • Tissue specificity

    Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
  • Pathway

    Sulfur metabolism; glutathione metabolism.
  • Involvement in disease

    Defects in GGT1 are a cause of glutathionuria (GLUTH) [MIM:231950]; also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease.
  • Sequence similarities

    Belongs to the gamma-glutamyltransferase family.
  • Post-translational

    N-glycosylated on both chains. Contains hexoses, hexosamines and sialic acid residues. Glycosylation profiles tested in kidney and liver tissues reveal the presence of tissue-specific and site-specific glycan composition, despite the overlap in composition among the N-glycans. A total of 36 glycan compositions, with 40 unique structures are observed. Up to 15 different glycans are observed at a single site, with site-specific variation in glycan composition. The difference in glycosylation profiles in the 2 tissues do not affect the enzyme activity.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • CD224 antibody
    • D22S672 antibody
    • D22S732 antibody
    • Gamma glutamyl transpeptidase antibody
    • Gamma glutamyltransferase 1 antibody
    • Gamma glutamyltranspeptidase 1 antibody
    • Gamma-glutamyltransferase 1 antibody
    • Gamma-glutamyltranspeptidase 1 light chain antibody
    • GGT 1 antibody
    • GGT antibody
    • GGT1 antibody
    • GGT1_HUMAN antibody
    • Glutamyl transpeptidase antibody
    • Glutathione hydrolase 1 antibody
    • GTG antibody
    • Leukotriene C4 hydrolase antibody
    • MGC96892 antibody
    • MGC96904 antibody
    • MGC96963 antibody
    • OTTHUMP00000028921 antibody
    • OTTHUMP00000197959 antibody
    see all


  • Anti-GGT1/GGT antibody - N-terminal (ab195662) at 0.3 µg/ml + human kidney lysate in RIPA buffer at 35 µg

    Predicted band size: 61 kDa

  • Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human liver tissue sections labeling GGT1/GGT with ab195662 at 5 µg/mL.


ab195662 has not yet been referenced specifically in any publications.

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