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Anti-Ghrelin antibody (ab217011)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin antibody (ab217011)

    Key features and details

    • Rabbit polyclonal to Ghrelin
    • Suitable for: IHC-P
    • Reacts with: Rat
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    Protein
    Product image
    Recombinant Human Ghrelin protein (ab89233)

    View more associated products

    Overview

    • Product name

      Anti-Ghrelin antibody
      See all Ghrelin primary antibodies
    • Description

      Rabbit polyclonal to Ghrelin
    • Host species

      Rabbit
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Rat
      Predicted to work with: Mouse, Human
    • Immunogen

      Synthetic peptide within Mouse Ghrelin aa 24-51 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
      Sequence:

      GSSFLSPEHQKAQQRKESKKPPAKLQPR


      Database link: Q9EQX0
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Rat stomach tissue.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      Preservative: 0.09% Sodium azide
      Constituents: 1% BSA, 50% Glycerol
    • Concentration information loading...
    • Purity

      Protein A purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Cardiovascular
      • Blood
      • Other
      • Signal Transduction
      • Growth Factors/Hormones
      • Hormones
      • Neuroscience
      • Neurology process
      • Metabolism
      • Cardiovascular
      • Atherosclerosis
      • Diabetes associated
      • Metabolism
      • Types of disease
      • Diabetes
      • Metabolism
      • Types of disease
      • Obesity
      • Metabolism
      • Types of disease
      • Heart disease

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human Ghrelin protein (ab89233)

    Applications

    Our Abpromise guarantee covers the use of ab217011 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P 1/100 - 1/500.

    Target

    • Function

      Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
      Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
    • Tissue specificity

      Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
    • Sequence similarities

      Belongs to the motilin family.
    • Post-translational
      modifications

      O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
      Amidation of Leu-98 is essential for obestatin activity.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession Q9UBU3 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 51738 Human
      • Entrez Gene: 58991 Mouse
      • Entrez Gene: 59301 Rat
      • Omim: 605353 Human
      • SwissProt: Q9UBU3 Human
      • SwissProt: Q9EQX0 Mouse
      • SwissProt: Q9QYH7 Rat
      • Unigene: 590080 Human
      • Unigene: 672979 Human
      • Unigene: 379095 Mouse
      see all
    • Alternative names

      • Appetite regulating hormone antibody
      • Ghrelin 27 antibody
      • Ghrelin 28 antibody
      • Ghrelin and obestatin prepropeptide antibody
      • Ghrelin antibody
      • Ghrelin/obestatin prepropeptide antibody
      • ghrl antibody
      • GHRL_HUMAN antibody
      • Growth hormone releasing peptide antibody
      • Growth hormone secretagogue antibody
      • Growth hormone-releasing peptide antibody
      • M46 protein antibody
      • Motilin related peptide antibody
      • Motilin-related peptide antibody
      • MTLRP antibody
      • Obestatin antibody
      • Protein M46 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin antibody (ab217011)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin antibody (ab217011)

      Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat stomach tissue labeling Ghrelin with ab217011 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab217011? Please let us know so that we can cite the reference in this datasheet.

    ab217011 has not yet been referenced specifically in any publications.

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