Overview

  • Product name

  • Description

    Guinea pig polyclonal to Ghrelin
  • Host species

    Guinea pig
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Sheep
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Ghrelin aa 24-51. Conjugated to carrier protein to enhance the immunological response.
    Sequence:

    GSSFLSPEHQRVQQRKESKKPPAKLQPR


    Database link: Q9UBU3

  • Positive control

    • IHC-P: Sheep abomasum tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab228497 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/3000.

No staining is evident when the primary antibody is pre-absorbed with 0.5 mg/ml of human Ghrelin.

Target

  • Function

    Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
  • Tissue specificity

    Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
  • Sequence similarities

    Belongs to the motilin family.
  • Post-translational
    modifications

    O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
    Amidation of Leu-98 is essential for obestatin activity.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Appetite regulating hormone antibody
    • Ghrelin 27 antibody
    • Ghrelin 28 antibody
    • Ghrelin and obestatin prepropeptide antibody
    • Ghrelin antibody
    • Ghrelin/obestatin prepropeptide antibody
    • ghrl antibody
    • GHRL_HUMAN antibody
    • Growth hormone releasing peptide antibody
    • Growth hormone secretagogue antibody
    • Growth hormone-releasing peptide antibody
    • M46 protein antibody
    • Motilin related peptide antibody
    • Motilin-related peptide antibody
    • MTLRP antibody
    • Obestatin antibody
    • Protein M46 antibody
    see all

Images

  • Paraffin-embedded sheep abomasum tissue stained for Ghrelin using ab228497 at 1/1000 dilution in immunohistochemical analysis, followed by a biotinylated secondary antibody.

References

ab228497 has not yet been referenced specifically in any publications.

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