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    ghrelin-peptide-ab199421.pdf

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Ghrelin peptide (ab199421)

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Key features and details

  • Suitable for: Blocking

Description

  • Product name

    Ghrelin peptide
    See all Ghrelin proteins and peptides
  • Animal free

    No
  • Nature

    Synthetic

Associated products

  • Corresponding Antibody

    • Anti-Ghrelin antibody (ab64325)

Specifications

Our Abpromise guarantee covers the use of ab199421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Ghrelin antibody (ab64325)

  • Form

    Liquid
  • Additional notes

    This is the blocking peptide for ab64325.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • Appetite regulating hormone
    • Ghrelin
    • Ghrelin 27
    • Ghrelin 28
    • Ghrelin and obestatin prepropeptide
    • Ghrelin/obestatin prepropeptide
    • ghrl
    • GHRL_HUMAN
    • Growth hormone releasing peptide
    • Growth hormone secretagogue
    • Growth hormone-releasing peptide
    • M46 protein
    • Motilin related peptide
    • Motilin-related peptide
    • MTLRP
    • Obestatin
    • Protein M46
    see all
  • Function

    Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
  • Tissue specificity

    Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
  • Sequence similarities

    Belongs to the motilin family.
  • Post-translational
    modifications

    O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
    Amidation of Leu-98 is essential for obestatin activity.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession Q9UBU3 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab199421? Please let us know so that we can cite the reference in this datasheet.

    ab199421 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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