Ghrelin peptide (ab199421)

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Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab199421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Ghrelin antibody (ab64325)

  • Form

    Liquid

  • Additional notes

    This is the blocking peptide for ab64325.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • Appetite regulating hormone
    • Ghrelin
    • Ghrelin 27
    • Ghrelin 28
    • Ghrelin and obestatin prepropeptide
    • Ghrelin/obestatin prepropeptide
    • ghrl
    • GHRL_HUMAN
    • Growth hormone releasing peptide
    • Growth hormone secretagogue
    • Growth hormone-releasing peptide
    • M46 protein
    • Motilin related peptide
    • Motilin-related peptide
    • MTLRP
    • Obestatin
    • Protein M46
    see all

  • Function

    Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.

  • Tissue specificity

    Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.

  • Sequence similarities

    Belongs to the motilin family.

  • Post-translational
    modifications

    O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
    Amidation of Leu-98 is essential for obestatin activity.

  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab199421 has not yet been referenced specifically in any publications.

Publishing research using ab199421? Please let us know so that we can cite the reference in this datasheet.

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